Maternal autoantibodies and congenital heart block: Clues from two consecutive pregnancies, one in which there was congenital complete heart block and one in which the fetus was healthy

Congenital complete heart block.

Congenital Complete Heart Block.

Few of the reported cases of congenital complete heart block have been over twenty years of age. It seems, therefore, worth reporting seven cases who are in good health at various ages between 22 and 42 years. This aetiological factor should, therefore, be thought of in middle-aged and even in elderly patients with complete heart block of unknown oetiology. Campbell and Suzman (1934), reporting...

Congenital complete heart block.

seven hours twenty minutes before delivery, the foetal heart sounds became audible. The very slow rate was noted. It was regular, and the provisional diagnosis of complete heart block was suggested. At delivery the condition of the infant was good: there was no cyanosis. Auscultation of the heart disclosed no murmurs. The ventricular rate fluctuated from timne to timie and varied between sixty ...

Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block.

BACKGROUND Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was con...

Familial congenital complete heart block and maternal systemic lupus erythematosis.

A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A review of the literature on familial complete heart block suggests that so-call...